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Introduction to Terpenes – Part 2

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Linalool is a monoterpene compound commonly found as a major component of the essential oils of several aromatic plant species, many of which are used in traditional medical systems as analgesic and anti-inflammatory remedies. Linalool, the natural occurring enantiomer, plays a major role in the anti-inflammatory activity displayed by different essential oils, suggesting that linalool-producing species are potentially anti-inflammatory agents.

Commonly extracted from lavender (Lavandula spp.), rose (Rosa spp.), basil (Ocimum basilicum), and neroli oil (Citrus aurantium).

Linalool has established sedative, antidepressant, anxiolytic, and immune potentiating effects and can represent a significant portion (< 6%) of the EO of cannabis (McPartland & Russo, 2001)

Linalool Fact Sheet

Uses

Aromatherapy specialists use linalool for its anti-anxiety effects. The claims for anti-anxiety effects are supported by research.
Research on mice has shown interesting promise for linalool in the treatment of Alzheimers Disease (Sabogal-Guáqueta et al, 2016).

Linalool is crucial in the release of vitamin E into the body making it a very significant terpene for healthy functioning (Peana et al., 2002).

According to the National Library of Medicine ((Russo, 2011), Linalool is considered to be an excellent:

  • Anxiolytic
  • Sedative
  • Antiepileptic
  • Antidepressant
  • Anti-inflammatory (Li et al., 2015)
  • Analgesic
  • Antipsychotic
  • Anti-convulsant (Elisabetsky et al., 1999)
With benefits like these, it’s no wonder it’s often used in products designed to help people relax.
References

Elisabetsky, E., Silva Brum, L. F., & Souza, D. O. (1999). Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine, 6(2), 107–113. Link

Li, Y., Lv, O., Zhou, F., Li, Q., Wu, Z., & Zheng, Y. (2015). Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2. Neurochemical Research, 40(7), 1520–1525. Link

Peana, A. T., D’Aquila, P. S., Panin, F., Serra, G., Pippia, P., & Moretti, M. D. L. (2002). Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine, 9(8), 721–726. Link

Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364. Link

Sabogal-Guáqueta, A. M., Osorio, E., & Cardona-Gómez, G. P. (2016). Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer’s mice. Neuropharmacology, 102, 111–120. Link

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